Huxley Bertram Compaction Simulators with Containment

/in , , /by
Huxley Bertram provides containment as an option with the HB100 Compaction Simulator. A typical specification is as follows:
  • The enclosure contains compounds with data that supports the Roche guideline ‘3B’ also stated as equal to, or less than, OEL of 50 nanograms per cubic meter over an eight hour time-weighted average; also stated as Roche 3B level (< 50 ng/m3/TWA 8 hours).
  • The Simulator has the make-up air from the laboratory room passed through HEPA exhaust filters, and fans into the lab.
  • Movable Glove Panel Sash allows access to the machine for changes to configuration, cleaning, calibration and maintenance. The Sash moves vertically upwards for free access into the work space.
  • Four glove ports are located across the width of the door, giving access above and below the die table.
  • Light guards protect against hands being inserted whilst the machine is in operation.
  • A Pilz safety guard controller monitors containment related sensors and switches.
  • Two canister-pass-throughs of 200mm diameter are located one each on the right-hand and left-hand sides of the machine.
  • Pass-throughs accommodate all normal simulation testing requirements, but not components for re-configuring the machine for Hiestand testing or the reverse.
  • Supply includes 2 sets of filters and continuous liners, one of which will be used during testing. One set of gloves is provided.
  • The enclosure is constructed from 304 electropolished stainless steel with acrylic viewing panels.

If you would like more information please get in touch with us at – info@huxleybertram.com

 

 

 

TeraSolve – Terahertz Spectroscopy Tool Collaboratively Developed by Huxley Bertram

/in , , /by
Huxley Bertram is proud to be involved in collaboratively developing new and leading technology, TeraSolve, it uses terahertz spectroscopy to measure the total porosity of tablets.
Together with TeraView (https://teraview.com/), Axel Zeitler from University of Cambridge (https://www.ceb.cam.ac.uk/) and Daniel Markl from the University of Strathclyde, Huxley Bertram has developed a completely new terahertz spectroscopy sensor that can be used for at-line measurements for the development and quality testing of immediate release tablets in the pharmaceutical industry.
The instrument is capable of measuring the total porosity of tablets without any sample preparation in transmission in less than a second. The results of the measurement can be monitored in real-time and stored for subsequent analysis such as chemometric analysis using commonly available tools such as SIPAT.
Further research is in progress to translate this technology into in-line and/or on-line sensing applications for the pharmaceutical industry. The TeraSolve was developed as part of a collaborative project with GSK funded by Innovate UK, project reference 104196.
For more information, contact us at info@huxleybertram.com

Compaction Simulation Forum US June 2019

/in , /by

There were over 70 attendees at the Compaction Simulator Forum in the US. Martin Bennett and Jean Le Floch attended for Huxley Bertram. Adhesion was one of the key topics at the forum.

 

Compaction Simulation Forum US June 2019

/in , /by

We are pleased to announce that Huxley Bertram is once again sponsoring the Compaction Simulator Forum in the US. It  takes place 04-05 June 2019 in New Brunswick, New Jersey – more details here.

Compaction Simulation Forum Europe Report

/in , /by

The eighth Compaction Simulation Forum (CSF2018-EU) was held at University of Cambridge 17- 19 September 2018. Sponsored by Huxley Bertram, the Forum gathered 60 attendees from the UK, Europe and the USA. Sixteen universities from eight countries were represented, as well as eight pharmaceutical companies and ten equipment/services vendors. Leading UK companies such as GSK, Pfizer, BMS and Johnson Matthey were in attendance. The scientific programme included keynote addresses, podium presentations, flash presentations and posters. Martin Bennett, Huxley Bertram’s compaction expert, presented on the important effects of rotary tablet press elasticity.

Once again the CSF reflected a growing interest in numerical simulation as a companion to experimental simulation. Other important trends displayed at the event included:

  • Terahertz-based porosity assessment of pharmaceutical tablet
  • Continuous tablet production
  • The importance of servo-hydraulic compaction simulators in the field of tableting research.

Two similar events are in the planning process for 2019.

(Photographs courtesy of Department of Chemical Engineering and Biotechnology, University of Cambridge, and Daniel Markl, University of Strathclyde.)

Compaction Simulator Forum Cambridge 17-19 Sept 2018

/in , , /by

Huxley Bertram is attending the Compaction Simulator Forum in Cambridge, UK. For more information on the forum, visit www.compactionsimulation.com

Huxley Bertram Sponsors Compaction Simulator Forum USA

/in , , /by

Huxley Bertram is attending the Compaction Simulator Forum in San Francisco, USA, this week. Once again, we are sponsoring the forum too. For more information on the forum, visit www.compactionsimulation.com

UPDATE

We are pleased to report that the event was very successful attended by many major pharmaceutical firms and universities from across the USA and around the world.